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(2015) Reperfusion injury and reactive oxygen species: the evolution of a concept

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Losing weight too quickly can lead to muscle loss , excess skin , a slower metabolism, and nutrient deficiencies

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Wootten D, Christopoulos A, Marti-Solano M, Babu MM, Sexton PM

The mice models behave normally without signs for pain, stress, or discomfort and did not lose any weight (Fig